New insights into the biology of tissue factor pathway inhibitor.

@article{Maroney2015NewII,
  title={New insights into the biology of tissue factor pathway inhibitor.},
  author={Susan A. Maroney and Alan E Mast},
  journal={Journal of thrombosis and haemostasis : JTH},
  year={2015},
  volume={13 Suppl 1},
  pages={S200-7}
}
Tissue factor pathway inhibitor (TFPI) dampens the initiation of blood coagulation by inhibiting two potent procoagulant complexes, tissue factor-factor VIIa (TF-FVIIa) and early forms of prothrombinase. TFPI isoforms, TFPIα and TFPIβ, result from alternative splicing of mRNA, producing distinct C-terminal ends of the two proteins. Both isoforms inhibit TF-FVIIa, but only TFPIα can inhibit early forms of prothrombinase by binding of its positively charged C-terminus with high affinity to the… CONTINUE READING