New insights into the aetiology of colorectal cancer from genome-wide association studies

@article{Tenesa2009NewII,
  title={New insights into the aetiology of colorectal cancer from genome-wide association studies},
  author={Albert Tenesa and Malcolm G Dunlop},
  journal={Nature Reviews Genetics},
  year={2009},
  volume={10},
  pages={353-358}
}
Genome-wide association studies have recently identified ten common genetic variants associated with colorectal cancer susceptibility, several suggesting the involvement of components of the transforming growth factor beta (TGFβ) superfamily signalling pathway. To date, no causal sequence variants have been identified, and risk seems to be mediated through effects on gene regulation. Several markers are located close to poorly characterized genes or in gene deserts, raising challenges for… CONTINUE READING
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A genome - wide association study identifies colorectal cancer susceptibility loci on chromosomes 10 p 14 and 8 q 23 . 3

  • R. S. Houlston
  • Nature Genet .
  • 2008

Genome - wide association scan identifies a colorectal cancer susceptibility locus on 11 q 23 and replicates risk loci at 8 q 24 and 18 q 21

  • A. C. Antoniou, D. F. Easton
  • Nature Genet .
  • 2008

Genome - wide association studies for complex traits : consensus , uncertainty and challenges

  • A. Tenesa
  • Nature Rev . Genet .
  • 2008

Germline allelespecific expression of TGFBR 1 confers an increased risk of colorectal cancer

  • G. C. Blobe, W. P. Schiemann, H. F. Lodish
  • Science
  • 2008

Meta - analysis of genome - wide association data identifies four new susceptibility loci for colorectal cancer

  • J. R. Howe
  • Nature Genet .
  • 2008

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