New insights into the Lpt machinery for lipopolysaccharide transport to the cell surface: LptA-LptC interaction and LptA stability as sensors of a properly assembled transenvelope complex.

@article{Sperandeo2011NewII,
  title={New insights into the Lpt machinery for lipopolysaccharide transport to the cell surface: LptA-LptC interaction and LptA stability as sensors of a properly assembled transenvelope complex.},
  author={P. Sperandeo and R. Villa and A. Martorana and M{\'a}ria {\vS}amal{\'i}kov{\'a} and R. Grandori and G. Deh{\`o} and A. Polissi},
  journal={Journal of bacteriology},
  year={2011},
  volume={193 5},
  pages={
          1042-53
        }
}
Lipopolysaccharide (LPS) is a major glycolipid present in the outer membrane (OM) of Gram-negative bacteria. The peculiar permeability barrier of the OM is due to the presence of LPS at the outer leaflet of this membrane that prevents many toxic compounds from entering the cell. In Escherichia coli LPS synthesized inside the cell is first translocated over the inner membrane (IM) by the essential MsbA flippase; then, seven essential Lpt proteins located in the IM (LptBCDF), in the periplasm… Expand
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