New insights into the Lpt machinery for lipopolysaccharide transport to the cell surface: LptA-LptC interaction and LptA stability as sensors of a properly assembled transenvelope complex.

@article{Sperandeo2011NewII,
  title={New insights into the Lpt machinery for lipopolysaccharide transport to the cell surface: LptA-LptC interaction and LptA stability as sensors of a properly assembled transenvelope complex.},
  author={P. Sperandeo and R. Villa and A. Martorana and M{\'a}ria {\vS}amal{\'i}kov{\'a} and R. Grandori and G. Deh{\`o} and A. Polissi},
  journal={Journal of bacteriology},
  year={2011},
  volume={193 5},
  pages={
          1042-53
        }
}
Lipopolysaccharide (LPS) is a major glycolipid present in the outer membrane (OM) of Gram-negative bacteria. The peculiar permeability barrier of the OM is due to the presence of LPS at the outer leaflet of this membrane that prevents many toxic compounds from entering the cell. In Escherichia coli LPS synthesized inside the cell is first translocated over the inner membrane (IM) by the essential MsbA flippase; then, seven essential Lpt proteins located in the IM (LptBCDF), in the periplasm… Expand
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The Lack of the Essential LptC Protein in the Trans-Envelope Lipopolysaccharide Transport Machine Is Circumvented by Suppressor Mutations in LptF, an Inner Membrane Component of the Escherichia coli Transporter
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The Escherichia coli Lpt transenvelope protein complex for lipopolysaccharide export is assembled via conserved structurally homologous domains.
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Characterization of lipopolysaccharide transport protein complex
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Structural insight into lipopolysaccharide transport from the Gram-negative bacterial inner membrane to the outer membrane.
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Functional Characterization of E. coli LptC: Interaction with LPS and a Synthetic Ligand
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Lipopolysaccharide transport to the cell surface: periplasmic transport and assembly into the outer membrane
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References

SHOWING 1-10 OF 43 REFERENCES
Functional analysis of the protein machinery required for transport of lipopolysaccharide to the outer membrane of Escherichia coli.
  • 195
  • PDF
Characterization of the two-protein complex in Escherichia coli responsible for lipopolysaccharide assembly at the outer membrane
  • 165
  • PDF
Characterization of lptA and lptB, two essential genes implicated in lipopolysaccharide transport to the outer membrane of Escherichia coli.
  • 193
  • PDF
Periplasmic orientation of nascent lipid A in the inner membrane of an Escherichia coli LptA mutant
  • 46
  • PDF
Identification of two inner-membrane proteins required for the transport of lipopolysaccharide to the outer membrane of Escherichia coli
  • 201
  • PDF
The lipopolysaccharide transport system of Gram-negative bacteria.
  • 137
Identification of an outer membrane protein required for the transport of lipopolysaccharide to the bacterial cell surface.
  • 229
  • PDF
Structure and Functional Analysis of LptC, a Conserved Membrane Protein Involved in the Lipopolysaccharide Export Pathway in Escherichia coli*
  • 101
  • Highly Influential
  • PDF
Lipopolysaccharide Transport to the Bacterial Outer Membrane in Spheroplasts*
  • 86
  • PDF
Novel structure of the conserved gram-negative lipopolysaccharide transport protein A and mutagenesis analysis.
  • 121
...
1
2
3
4
5
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