New insights into the HCV quasispecies and compartmentalization.

  title={New insights into the HCV quasispecies and compartmentalization.},
  author={Patrizia Farci},
  journal={Seminars in liver disease},
  volume={31 4},
Hepatitis C virus (HCV) is a hepatotropic RNA virus with an extraordinary propensity to persist in the vast majority of infected individuals. During replication, because of the inherent infidelity of the viral RNA polymerase, each progeny RNA genome contains mutations that lead to a continuous diversification of the viral population. Consequently, HCV circulates in vivo as a quasispecies, which is a dynamic distribution of divergent but closely related genomes subjected to a continuous process… CONTINUE READING