New insights into respirable protein powder preparation using a nano spray dryer.

@article{Brki2011NewII,
  title={New insights into respirable protein powder preparation using a nano spray dryer.},
  author={Kurt B{\"u}rki and I Jeon and Cordin Arpagaus and Gabriele Betz},
  journal={International journal of pharmaceutics},
  year={2011},
  volume={408 1-2},
  pages={248-56}
}
In this study the Nano Spray Dryer B-90 (BÜCHI Labortechnik AG, Flawil, Switzerland) was evaluated with regard to the drying of proteins and the preparation of respirable powders in the size range of 1-5 μm. β-galactosidase was chosen as a model protein and trehalose was added as a stabilizer. The influence of inlet temperature, hole size of the spray cap membrane and ethanol concentration in the spray solution was studied using a 3³ full factorial design. The investigated responses were enzyme… CONTINUE READING

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