New insights into replication origin characteristics in metazoans

@article{Cayrou2012NewII,
  title={New insights into replication origin characteristics in metazoans},
  author={Christelle Cayrou and P. Coulombe and Aurore Puy and S. Rialle and Noam Kaplan and E. Segal and M. Méchali},
  journal={Cell Cycle},
  year={2012},
  volume={11},
  pages={658 - 667}
}
We recently reported the identification and characterization of DNA replication origins (Oris) in metazoan cell lines. Here, we describe additional bioinformatic analyses showing that the previously identified GC-rich sequence elements form origin G-rich repeated elements (OGREs) that are present in 67% to 90% of the DNA replication origins from Drosophila to human cells, respectively. Our analyses also show that initiation of DNA synthesis takes place precisely at 160 bp (Drosophila) and 280… Expand
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TLDR
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Allele-specific analysis of DNA replication origins in mammalian cells
TLDR
It is proposed that although G4-forming sequences are abundant in replication origins, an asymmetry in nucleotide distribution, which increases the propensity of origins to unwind and adopt non-B DNA structure, rather than the ability to form G4, is directly associated with origin activity. Expand
Involvement of G-quadruplex regions in mammalian replication origin activity
TLDR
The functional role of G4 elements in DNA replication initiation is revealed, showing that OGRE/G4 sequences are involved in the activation of DNA replication, but not in the pre-replication complex formation. Expand
DNA replication origins.
TLDR
Close examination of bacterial and archaeal replication origins reveals an array of DNA sequence motifs that position individual initiator protein molecules and promote initiator oligomerization on origin DNA. Expand
Straight core structure of DNA replication origins in the mammalian AMPD2 locus
TLDR
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