New insights into nitric oxide and coronary circulation.

@article{Gattullo1999NewII,
  title={New insights into nitric oxide and coronary circulation.},
  author={D. Gattullo and P. Pagliaro and N. Marsh and G. Losano},
  journal={Life sciences},
  year={1999},
  volume={65 21},
  pages={
          2167-74
        }
}
Since its discovery over 20 years ago as an intercellular messenger, nitric oxide (NO), has been extensively studied with regard to its involvement in the control of the circulation and, more recently, in the prevention of atherosclerosis. The importance of NO in coronary blood flow control has also been recognized. NO-independent vasodilation causes increased shear stress within the blood vessel which, in turn, stimulates endothelial NO synthase activation, NO release and prolongation of… Expand
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