New insights into mTOR signaling: mTORC2 and beyond.

  title={New insights into mTOR signaling: mTORC2 and beyond.},
  author={Dario R Alessi and Laura R. Pearce and J. M. Garc{\'i}a-Mart{\'i}nez},
  journal={Science signaling},
  volume={2 67},
The mammalian target of rapamycin complex 2 (mTORC2) plays critical roles in regulating cell growth and proliferation. mTORC2 promotes the activation of the serum glucocorticoid-induced protein kinase (SGK). This mTOR complex also promotes the constitutive phosphorylation of proline-directed serine or threonine sites in the turn motif of Akt and protein kinase C isoforms. mTORC2 may control phosphorylation of the turn motif by promoting the activity of a kinase that targets the Ser/Thr-Pro… CONTINUE READING