New insights into functions, regulation, and pathological roles of tight junctions in kidney tubular epithelium.

@article{Szszi2014NewII,
  title={New insights into functions, regulation, and pathological roles of tight junctions in kidney tubular epithelium.},
  author={Katalin Sz{\'a}szi and Yasaman Amoozadeh},
  journal={International review of cell and molecular biology},
  year={2014},
  volume={308},
  pages={205-71}
}
Epithelial tight junctions (TJs) seal off the intercellular space to generate a paracellular barrier as well as a selective transport pathway. They also maintain apicobasal polarization of cells. In addition, TJs serve as signaling platforms that orchestrate many epithelial functions. The past years have brought about a remarkable increase in our understanding of the structure and function of TJs. The overall aim of this review is to provide an update on this new knowledge, with special… CONTINUE READING