New insights into function of the growth plate: clinical observations, chondrocyte enlargement and a possible role for membrane transporters.

@article{Bush2008NewII,
  title={New insights into function of the growth plate: clinical observations, chondrocyte enlargement and a possible role for membrane transporters.},
  author={Peter G. Bush and Andrew C Hall and Malcolm F Macnicol},
  journal={The Journal of bone and joint surgery. British volume},
  year={2008},
  volume={90 12},
  pages={1541-7}
}
The mammalian growth plate is a complex structure which is essential for the elongation of long bones. However, an understanding of how the growth plate functions at the cellular level is lacking. This review, summarises the factors involved in growth-plate regulation, its failure and the consequence of injury. We also describe some of the cellular mechanisms which underpin the increase in volume of the growth-plate chondrocyte which is the major determinant of the rate and extent of bone… CONTINUE READING

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