New insights into endotoxin-induced activation of macrophages: involvement of a K+ channel in transmembrane signaling.

@article{Blunck2001NewII,
  title={New insights into endotoxin-induced activation of macrophages: involvement of a K+ channel in transmembrane signaling.},
  author={Rikard Blunck and Olaf Scheel and Mareike Mueller and Klaus Brandenburg and Ulrike Seitzer and Ulrich Seydel},
  journal={Journal of immunology},
  year={2001},
  volume={166 2},
  pages={1009-15}
}
LPS (endotoxins) activate cells of the human immune system, among which are monocytes and macrophages, to produce endogenous mediators. These regulate the immune response, but may also cause severe harm leading to septic shock. The activation of monocytes/macrophages by LPS is mediated by a membrane-bound LPS receptor, mCD14. As mCD14 lacks a transmembrane domain, a further protein is required for the signal transducing step to the cell interior. Here we show, using excised outside-out membrane… CONTINUE READING