New insights into brain BDNF function in normal aging and Alzheimer disease
@article{TapiaArancibia2008NewII, title={New insights into brain BDNF function in normal aging and Alzheimer disease}, author={Luc{\'i}a Tapia-Arancibia and Esteban Aliaga and Michelle Silhol and Sandor Arancibia}, journal={Brain Research Reviews}, year={2008}, volume={59}, pages={201-220} }
471 Citations
BDNF in the Aged Brain: Translational Implications for Parkinson's Disease.
- BiologyAustin neurology & neurosciences
- 2017
The extent of the existing literature on age-related BDNF changes is summarized, and the relevance of these changes as a factor potentially impacting therapeutics in aged parkinsonian subjects is discussed.
Brain-Derived Neurotrophic Factor: A Key Molecule for Memory in the Healthy and the Pathological Brain
- Biology, PsychologyFront. Cell. Neurosci.
- 2019
It is proposed that, although BDNF may not be a valid biomarker for neurodegenerative/neuropsychiatric diseases, it could be thought of as a marker that specifically relates to the occurrence and/or progression of the mnemonic symptoms that are common to many pathological conditions.
Brain-Derived Neurotrophic Factor Expression in Individuals With Schizophrenia and Healthy Aging: Testing the Accelerated Aging Hypothesis of Schizophrenia
- Medicine, PsychologyCurrent Psychiatry Reports
- 2017
There is a marked decrease in BDNF levels in the frontal regions and in the periphery among older individuals and those with schizophrenia; however, data for BDNF expression in the occipital, parietal, and temporal cortices and the hippocampus is inconclusive.
Epigenetic Enhancement of BDNF Signaling Rescues Synaptic Plasticity in Aging
- BiologyThe Journal of Neuroscience
- 2011
These findings suggest that age-dependent declines in chromatin histone acetylation and the resulting changes in BDNF expression and signaling are key mechanisms underlying the deterioration of synaptic function and structure in the aging brain.
The Role of BDNF on Aging-Modulation Markers
- BiologyBrain sciences
- 2020
Results show that low dose BDNF sequentially kinetic activated (SKA) is able to induce the endogenous production of BDNF, using its receptor TrkB and influencing the apolipoprotein E expression, confirming the hypothesis of a fine endogenous regulatory effect exerted by BDNF SKA in maintaining the health of both neurons and astrocytes.
Altered NCAM expression associated with the cholinergic system in Alzheimer's disease.
- Biology, PsychologyJournal of Alzheimer's disease : JAD
- 2010
The relationship between levels of synaptic markers (NCAM and BDNF), neurochemical measurements, and clinical data suggest a potential involvement of NCAM expressing neurons in the cognitive deficits in AD.
Alzheimer disease and neuroplasticity: New approaches and new targets in pharmacotherapy
- Biology
- 2012
The main objective of this review article is to update the knowledge on AD in the light of the present literature and discuss the new approaches and targets such as neuroplasticity hypothesis of AD and new candidate drugs.
Reduced neuroplasticity in aged rats: a role for the neurotrophin brain-derived neurotrophic factor
- Biology, PsychologyNeurobiology of Aging
- 2013
The involvement of BDNF, NGF and GDNF in aging and Alzheimer's disease.
- BiologyAging and disease
- 2015
Considering that aging and AD are related to cognitive impairment, here it is discussed the involving of neurotrophic factors in the aging process and AD.
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