New insights into brain BDNF function in normal aging and Alzheimer disease

@article{TapiaArancibia2008NewII,
  title={New insights into brain BDNF function in normal aging and Alzheimer disease},
  author={L. Tapia-Arancibia and E. Aliaga and M. Silhol and S. Arancibia},
  journal={Brain Research Reviews},
  year={2008},
  volume={59},
  pages={201-220}
}
The decline observed during aging involves multiple factors that influence several systems. It is the case for learning and memory processes which are severely reduced with aging. It is admitted that these cognitive effects result from impaired neuronal plasticity, which is altered in normal aging but mainly in Alzheimer disease. Neurotrophins and their receptors, notably BDNF, are expressed in brain areas exhibiting a high degree of plasticity (i.e. the hippocampus, cerebral cortex) and are… Expand
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