New insights into bioactivation of organic nitrates, nitrate tolerance and cross-tolerance

@article{Daiber2007NewII,
  title={New insights into bioactivation of organic nitrates, nitrate tolerance and cross-tolerance},
  author={Dr. Andreas Daiber and Philip Wenzel and Matthias Oelze and Thomas F. M{\"u}nzel},
  journal={Clinical Research in Cardiology},
  year={2007},
  volume={97},
  pages={12-20}
}
Organic nitrates still represent a group of very effective anti-ischemic drugs used for the treatment of patients with stable angina, acute myocardial infarction and chronic congestive heart failure. Long-term therapy with organic nitrates, however, results in a rapid development of nitrate tolerance blunting their hemodynamic and antiischemic efficacy. Recent studies revealed that mitochondrial reactive oxygen species (ROS) formation and a subsequent oxidative inactivation of nitrate reductase… CONTINUE READING