New insights into Alzheimer's disease pathogenesis: the involvement of neuroligins in synaptic malfunction.

@article{Sindi2015NewII,
  title={New insights into Alzheimer's disease pathogenesis: the involvement of neuroligins in synaptic malfunction.},
  author={Ikhlas A. Sindi and Peter Ronald Dodd},
  journal={Neurodegenerative disease management},
  year={2015},
  volume={5 2},
  pages={
          137-45
        }
}
Synaptic damage is a key hallmark of Alzheimer's disease and the best correlate with cognitive decline ante mortem. Signature protein combinations arrayed at tightly apposed pre- and post-synaptic sites characterize different types of synapse. Neuroligins are postsynaptic cell adhesion molecules that interact with neurexins across the synaptic cleft. These pairings recruit receptors, channels and signal transduction molecules to the synapse, and help mediate trans-synaptic transmission… CONTINUE READING
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