New insights in systemic juvenile idiopathic arthritis--from pathophysiology to treatment.

@article{Frosch2008NewII,
  title={New insights in systemic juvenile idiopathic arthritis--from pathophysiology to treatment.},
  author={Michael Frosch and Johannes Roth},
  journal={Rheumatology},
  year={2008},
  volume={47 2},
  pages={121-5}
}
Systemic juvenile idiopathic arthritis (SJIA) is characterized by the clinical features of remitting fever, a typical skin rash and arthritis. Many patients show frequent flares or persistent disease activity with significant morbidity and serious complications. Recent investigations in the pathophysiology of SJIA have focused on mediators of the innate immune system. Especially IL-1beta, IL-6 and IL-18 as well as phagocyte-specific S100-proteins (S100A8, S100A9 and S100A12) are correlated with… CONTINUE READING

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