New insights in bilirubin metabolism and their clinical implications.

  title={New insights in bilirubin metabolism and their clinical implications.},
  author={Eva Sticova and Milan Jirsa},
  journal={World journal of gastroenterology},
  volume={19 38},
Bilirubin, a major end product of heme breakdown, is an important constituent of bile, responsible for its characteristic colour. Over recent decades, our understanding of bilirubin metabolism has expanded along with the processes of elimination of other endogenous and exogenous anionic substrates, mediated by the action of multiple transport systems at the sinusoidal and canalicular membrane of hepatocytes. Several inherited disorders characterised by impaired bilirubin conjugation (Crigler… CONTINUE READING
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