New insights from old bones: DNA preservation and degradation in permafrost preserved mammoth remains

@inproceedings{Schwarz2009NewIF,
  title={New insights from old bones: DNA preservation and degradation in permafrost preserved mammoth remains},
  author={Carsten Schwarz and R{\'e}gis Debruyne and Melanie Kuch and Elizabeth A. McNally and Henry P. Schwarcz and Andrew D. Aubrey and Jeffrey Bada and Hendrik N Poinar},
  booktitle={Nucleic acids research},
  year={2009}
}
Despite being plagued by heavily degraded DNA in palaeontological remains, most studies addressing the state of DNA degradation have been limited to types of damage which do not pose a hindrance to Taq polymerase during PCR. Application of serial qPCR to the two fractions obtained during extraction (demineralization and protein digest) from six permafrost mammoth bones and one partially degraded modern elephant bone has enabled further insight into the changes which endogenous DNA is subjected… CONTINUE READING

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