New inhibitors of the mammalian target of rapamycin signaling pathway for cancer.

@article{Albert2010NewIO,
  title={New inhibitors of the mammalian target of rapamycin signaling pathway for cancer.},
  author={S{\'e}bastien Albert and Maria Serova and Chantal Dreyer and Marie-Paule Sablin and Sandrine J. Faivre and Eric Raymond},
  journal={Expert opinion on investigational drugs},
  year={2010},
  volume={19 8},
  pages={919-30}
}
IMPORTANCE OF THE FIELD Contrasting with the broad activation of the PI3K/AKT/mammalian target of rapamycin (mTOR) survival pathway in most cancer, activity of rapalogues appears to be restricted to a few tumor types. AREAS COVERED IN THIS REVIEW The analysis of molecular activity of the PI3K/AKT/mTOR pathway and resistance mechanisms of rapamycin and rapalogues led to the development of several inhibitory molecules. WHAT THE READER WILL GAIN New anticancer agents including PI3K inhibitors… CONTINUE READING

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