New indolicidin analogues with potent antibacterial activity.

@article{Ryge2004NewIA,
  title={New indolicidin analogues with potent antibacterial activity.},
  author={Trine Skovlund Ryge and Xavier Doisy and Dan Ifrah and John Elmerdahl Olsen and Paul Robert Hansen},
  journal={The journal of peptide research : official journal of the American Peptide Society},
  year={2004},
  volume={64 5},
  pages={
          171-85
        }
}
Indolicidin is a 13-residue antimicrobial peptide amide, ILPWKWPWWPWRR-NH2, isolated from the cytoplasmic granules of bovine neutrophils. Indolicidin is active against a wide range of microorganisms and has also been shown to be haemolytic and cytotoxic towards erythrocytes and human T lymphocytes. The aim of the present paper is two-fold. First, we examine the importance of tryptophan in the antibacterial activity of indolicidin. We prepared five peptide analogues with the format ILPXKXPXXPXRR… CONTINUE READING

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