New in vitro model to study the effect of antibiotic concentration and rate of elimination on antibacterial activity.

@article{Grasso1978NewIV,
  title={New in vitro model to study the effect of antibiotic concentration and rate of elimination on antibacterial activity.},
  author={Silvana Grasso and G. Meinardi and I de Carneri and V. Tamassia},
  journal={Antimicrobial agents and chemotherapy},
  year={1978},
  volume={13 4},
  pages={570-6}
}
A new apparatus is described which serves to investigate the in vitro antibacterial activity of antibiotics as a function of different concentration time curves. The apparatus can be adjusted to simulate the biexponential serum level curves observed in vivo after oral or intramuscular administration. Preliminary studies were carried out with a cephalosporin derivative, cefazolin, against Escherichia coli and Klebsiella sp. strains simulating initial concentrations of 5, 10, and 20 mug/ml that… CONTINUE READING
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