New icetexane and 20 norabietane diterpenes with trypanocidal activity from Dracocephalum komarovi.

@article{Uchiyama2003NewIA,
  title={New icetexane and 20 norabietane diterpenes with trypanocidal activity from Dracocephalum komarovi.},
  author={Nahoko Uchiyama and Fumiyuki Kiuchi and Michiho Ito and Gisho Honda and Yoshio Takeda and Olimjon K. Khodzhimatov and Ozodbek A. Ashurmetov},
  journal={Journal of natural products},
  year={2003},
  volume={66 1},
  pages={128-31}
}
Two new icetexane diterpenes, cyclocoulterone (1) and komaroviquinone (2), and a novel 20-norabietane diterpene, dracocephalone A (3), were isolated from Dracocephalum komarovi. Their structures were elucidated by extensive analyses of spectral data. Komaroviquinone (2) showed strong trypanocidal activity against epmastigotes of Trypanosoma cruzi, the causative agent of American trypanosomiasis, with a minimum lethal concentration of 0.4 micro M. 

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Two new icetexane diterpenes , cyclocoulterone ( 1 ) and komaroviquinone ( 2 ) , and a novel 20-norabietane diterpene , dracocephalone A ( 3 ) , were isolated from Dracocephalum komarovi .
Two new icetexane diterpenes , cyclocoulterone ( 1 ) and komaroviquinone ( 2 ) , and a novel 20-norabietane diterpene , dracocephalone A ( 3 ) , were isolated from Dracocephalum komarovi .
Komaroviquinone ( 2 ) showed strong trypanocidal activity against epmastigotes of Trypanosoma cruzi , the causative agent of American trypanosomiasis , with a minimum lethal concentration of 0.4 micro M.
Komaroviquinone ( 2 ) showed strong trypanocidal activity against epmastigotes of Trypanosoma cruzi , the causative agent of American trypanosomiasis , with a minimum lethal concentration of 0.4 micro M.
Two new icetexane diterpenes , cyclocoulterone ( 1 ) and komaroviquinone ( 2 ) , and a novel 20-norabietane diterpene , dracocephalone A ( 3 ) , were isolated from Dracocephalum komarovi .
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