New iantherans from the marine sponge Ianthella quadrangulata: novel agonists of the P2Y(11) receptor.

@article{Greve2007NewIF,
  title={New iantherans from the marine sponge Ianthella quadrangulata: novel agonists of the P2Y(11) receptor.},
  author={Hendrik Greve and Sabine Meis and Matthias U Kassack and Stefan Kehraus and Anja Krick and Anthony David Wright and Gabriele M K{\"o}nig},
  journal={Journal of medicinal chemistry},
  year={2007},
  volume={50 23},
  pages={5600-7}
}
Three new iantherans, iso-iantheran A (1), 8-carboxy-iso-iantheran A (2), and iso-iantheran B (4) were isolated together with two further new brominated tyrosine-derived metabolites 5 and 6 from the polar extract of the Australian marine sponge Ianthella quadrangulata. Structures were elucidated on the basis of extensive spectral analysis. The dimeric benzofuran skeleton including a 2,3-dihydroxy-1,3-butadiene disulfate moiety found in 1, 2, and 4 is a unique feature of iantherans and to date… CONTINUE READING

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