New hydrazone derivatives of adriamycin and their immunoconjugates--a correlation between acid stability and cytotoxicity.

@article{Kaneko1991NewHD,
  title={New hydrazone derivatives of adriamycin and their immunoconjugates--a correlation between acid stability and cytotoxicity.},
  author={Takushi Kaneko and David Willner and Ivo Monkovic and Jay O. Knipe and Gary R. Braslawsky and Robert S. Greenfield and D. M. Vyas},
  journal={Bioconjugate chemistry},
  year={1991},
  volume={2 3},
  pages={133-41}
}
New N-substituted hydrazine linkers were synthesized and their hydrazone derivatives of adriamycin were prepared. These functionalized adriamycin derivatives were conjugated with a monoclonal antibody, 5E9. The release rate of adriamycin from the hydrazones and from some of the conjugates was studied, and their relationship to the IC50's of the conjugate against 5E9-positive Daudi cells was investigated.