New human V beta genes and polymorphic variants.

  title={New human V beta genes and polymorphic variants.},
  author={Aresio Plaza and Dwight H. Kono and Argyrios N. Theofilopoulos},
  journal={Journal of immunology},
  volume={147 12},
To extend the characterization of the human V beta gene repertoire, we utilized anchored or V beta-specific polymerase chain reaction to generate a large (approximately 200 clones) beta-chain library from the thymus of a single individual. Nine new V beta genes were identified, including single members for two new subfamilies (V beta 22 and 23), two new members of the V beta 5 subfamily, and one new member each for V beta 2, 6, 7, 9, and 12. Full-length sequences were also obtained for the… CONTINUE READING

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