New horizon of mucosal immunity and vaccines.

@article{Takahashi2009NewHO,
  title={New horizon of mucosal immunity and vaccines.},
  author={Ichiro Takahashi and Tomonori Nochi and Yoshikazu Yuki and Hiroshi Kiyono},
  journal={Current opinion in immunology},
  year={2009},
  volume={21 3},
  pages={
          352-8
        }
}
Progress in the past quarter-century on understanding the molecular, cellular, and in vivo components of the mucosal immune system have allowed us to develop a practical strategy for a novel mucosal vaccine. The mucosal immune system can induce secretory IgA (SIgA) and serum IgG responses to provide two layers of defense against mucosal pathogens. For SIgA-mediated immunity in the gastrointestinal tract, the gut-associated lymphoid tissue contains both the tissue-dependent and tissue… CONTINUE READING
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