New high mobility group box 1 assay system.

  title={New high mobility group box 1 assay system.},
  author={Shingo Yamada and Keiko Yakabe and Junnichi Ishii and Hitoshi Imaizumi and Ikuro Maruyama},
  journal={Clinica chimica acta; international journal of clinical chemistry},
  volume={372 1-2},
BACKGROUND High-sensitivity sandwich ELISA methods have been developed using chemiluminescent substrates. HMGB1 (high mobility group box 1) protein has been shown to play a critical role in several inflammatory diseases and it may be involved in the development of atherosclerosis. METHODS Anti-human HMGB1 monoclonal antibodies and anti-peptide polyclonal antibodies against the peptide sequence (KPDAAKKGVVKAEK) with high antigenicity and different from the sequence of HMGB2 were developed, and… CONTINUE READING


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