New haplotypes in the Bedlington terrier indicate complexity in copper toxicosis

@article{Coronado2003NewHI,
  title={New haplotypes in the Bedlington terrier indicate complexity in copper toxicosis},
  author={Veronica A. Coronado and Deepti Damaraju and Ritva Kohijoki and Diane Wilson Cox},
  journal={Mammalian Genome},
  year={2003},
  volume={14},
  pages={483-491}
}
Copper toxicosis (CT) is an autosomal recessive disorder common in Bedlington terriers. Previously, the CT locus was mapped to canine Chromosome (Chr) 10q26 through linkage to marker C04107. Diagnosis, traditionally based on liver biopsy, has recently shifted to interpretation of the C04107 microsatellite alleles where allele 2 segregates with the disease with 90–95% accuracy. Recently, CT has been attributed to a deletion of exon 2 in the MURR1 gene. We also identified a deletion of exon 2 of… CONTINUE READING
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