New genetic loci that control susceptibility and symptoms of experimental allergic encephalomyelitis in inbred mice.

@article{Butterfield1998NewGL,
  title={New genetic loci that control susceptibility and symptoms of experimental allergic encephalomyelitis in inbred mice.},
  author={Russell J. Butterfield and Jayce D. Sudweeks and Elizabeth P. Blankenhorn and Robert Korngold and Joseph C. Marini and John A. Todd and Randall J. Roper and Cory Teuscher},
  journal={Journal of immunology},
  year={1998},
  volume={161 4},
  pages={1860-7}
}
Experimental allergic encephalomyelitis (EAE), the principal animal model of multiple sclerosis, is a genetically determined phenotype. In this study, analyses of the cumulative disease frequencies in parental, F1 hybrid, and F2 mice, derived from the EAE-susceptible SJL/J strain and the EAE-resistant B10.S/DvTe strain, confirmed that susceptibility to EAE is not inherited as a simple Mendelian trait. Whole genome scanning, using 150 informative microsatellite markers and a panel of 291… CONTINUE READING

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