New-generation platinum agents for solid tumors.

  title={New-generation platinum agents for solid tumors.},
  author={Neel T. Shah and Don S Dizon},
  journal={Future oncology},
  volume={5 1},
Cisplatin was one of the first chemotherapeutic agents to exhibit broad efficacy in solid tumors and it remains among the most widely used agents in the treatment of cancer. Its introduction inspired great efforts to design similarly effective platinum agents that overcome the three main limitations of cisplatin: toxicity, tumor resistance and poor oral bioavailability. However, 40 years after the initial discovery of cisplatin, only two platinum agents have garnered US FDA approval… CONTINUE READING

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