New generation antipsychotic drugs and compliance behaviour

@article{Voruganti2008NewGA,
  title={New generation antipsychotic drugs and compliance behaviour},
  author={Lakshmi N. P. Voruganti and Laura K. Baker and A. George Awad},
  journal={Current Opinion in Psychiatry},
  year={2008},
  volume={21},
  pages={133–139}
}
Purpose of review Antipsychotic therapy has been eclipsed by high rates of noncompliance; the problem was attributed to a lack of efficacy and the burden of side effects of neuroleptics. This review sought to examine whether the arrival of second generation (atypical) antipsychotic drugs with low side-effect liability and improved efficacy has helped to positively reinforce compliance behaviour among people treated for schizophrenia. Recent findings The number of studies that systematically… 
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    Expert review of neurotherapeutics
  • 2009
TLDR
The efficacy, tolerability and cost–effectiveness of long-acting risperidone in schizophrenia and bipolar disorder patients is discussed, and possibilities for how its role in clinical practice may change over the next 5 years are suggested.
A review of the adverse side effects associated with antipsychotics as related to their efficacy.
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There is reason to believe that a more personalised approach to antipsychotic treatment should be considered and screening for risk factors, screening for the appearance of side effects, as well as good communication with patients about the side effects and other options available are important tasks for clinicians to optimise concordance with medication.
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TLDR
Attitudes were principally determined by severity of side-effects and insight levels, and patients on SGAs had better attitudes, possibly because of less severe side- effects and greater insight among them.
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TLDR
There has been renewed interest in studying compliance behaviour in recent years propelled by two forces: an exponential growth in the development and testing of new therapeutic agents, and the growing burden of chronic diseases that require reliance on life-long medical treatments.
A STUDY TO ASSESS THE ATTITUDE ON RISK FACTORS ASSOCIATED WITH COMPLIANCE AND NONCOMPLIANCE OF NEUROLEPTIC TREATMENT AMONG PATIENTS WITH SCHIZOPHRENIA
  • Medicine, Psychology
  • 2011
TLDR
The attitude and the risk factors associated with compliance and non compliance of neuroleptic treatment among patients with Schizophrenia were assessed and it was revealed that the percentage level of risk factor among compliance andNon-compliance client was higher than expected.
Assessment of subjective cognitive and emotional effects of antipsychotic drugs. Effect by defect?
Cure or Curse? Ambivalent Attitudes Towards Neuroleptic Medication in Schizophrenia and Non-Schizophrenia Patients
TLDR
Self-reported neuroleptic non- compliance was more prevalent in psychosis patients than non-psychosis patients, and main reasons for non-compliance in both groups were forgetfulness, distrust in therapist, and no subjective need for treatment.
Antipsychotic treatment beyond antipsychotics: metacognitive intervention for schizophrenia patients improves delusional symptoms
TLDR
The results suggest that the combination of a cognition-oriented and a symptom-oriented approach ameliorate psychotic symptoms and cognitive biases and represents a promising complementary treatment for schizophrenia.
Adherence and Continuation of Treatment with First- and Second-generation Antipsychotics in Schizophrenia
TLDR
Patients on certain SGAs, notably olanzapine, are more likely to continue with their treatment that those on FGAs, and the influence of several socio-demographic and clinical variables on adherence in the two antipsychotic groups is examined.
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References

SHOWING 1-10 OF 65 REFERENCES
Adherence to atypical antipsychotic treatment among newly treated patients: a population-based study in schizophrenia.
TLDR
Patients who were prescribed their first atypical antipsychotic by a psychiatrist were more likely to be persistent, whereas those with a high comorbidity index and those aged 35 years or more were morelikely to be compliant.
Atypical antipsychotic drugs as a first-line treatment of schizophrenia: a rationale and hypothesis.
  • J. Lieberman
  • Psychology, Medicine
    The Journal of clinical psychiatry
  • 1996
TLDR
If the premise that atypical antipsychotic drug provide superior efficacy, reduced side effects, and the prospect of better compliance is accepted, their greatest impact may be when used in patients at the beginning of their illness.
Psychopharmacology: Perspectives on medication adherence and atypical antipsychotic medications.
TLDR
The arrival of atypical antipsychotics, with their lower rate of extrapyramidal effects, was greeted positively as an advance on the older drugs, and it was suggested that the lower rates of side effects would improve compliance, but few data to support this suggestion have been reported.
Effectiveness of atypical antipsychotic medications in reducing violent behavior among persons with schizophrenia in community-based treatment.
TLDR
Treatment with atypical antipsychotic medications should be considered as an important component of violence risk management for schizophrenia patients at risk for violent behavior.
Predictors of antipsychotic medication adherence in patients recovering from a first psychotic episode
Switching from conventional to novel antipsychotic drugs: results of a prospective naturalistic study
Adherence to conventional and atypical antipsychotics after hospital discharge.
TLDR
It is suggested that dose frequency is an important predictor of medication adherence and initially appeared to be associated with an adherence advantage over risperidone and conventional antipsychotics, but the apparent advantage may have been due to a usual care dose frequency practice that associated olanzapine more often with once-daily dosing.
Treatment adherence among patients with schizophrenia treated with atypical and typical antipsychotics
Effectiveness of antipsychotic drugs in patients with chronic schizophrenia.
TLDR
Olanzapine was the most effective in terms of the rates of discontinuation, and the efficacy of the conventional antipsychotic agent perphenazine appeared similar to that of quetiapine, risperidone, and ziprasidone.
Treatment persistence: a comparison among patients with schizophrenia who were initiated on atypical antipsychotic agents.
...
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