New gastroprotective ferruginol derivatives with selective cytotoxicity against gastric cancer cells.

@article{Espinoza2008NewGF,
  title={New gastroprotective ferruginol derivatives with selective cytotoxicity against gastric cancer cells.},
  author={Marlene Espinoza and Leonardo S. Santos and Cristina Theoduloz and Guillermo Schmeda-Hirschmann and Jaime A. Rodr{\'i}guez},
  journal={Planta medica},
  year={2008},
  volume={74 8},
  pages={
          802-8
        }
}
The diterpene ferruginol has shown a strong protective effect in animal gastric ulcer models. In the present work, we report the gastroprotective effect and cytotoxicity of 16 new semisynthetic ester derivatives of ferruginol. The gastroprotective effect of these compounds was assessed with the HCl/EtOH-induced gastric lesions model in mice and the cytotoxicity was measured using MRC-5 fibroblasts, gastric adenocarcinoma (AGS) and liver hepatoma Hep G2 cells. The compounds were tested for a… 
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