New functions for the NHERF family of proteins.

  title={New functions for the NHERF family of proteins.},
  author={Edward J. Weinman},
  journal={The Journal of clinical investigation},
  volume={108 2},
185 The sodium-hydrogen exchanger regulatory factor, NHERF (also called EBP50), was isolated initially as a necessary cofactor in cAMP-associated inhibition of the renal brush border sodium-hydrogen exchanger (NHE3) (1). Shortly thereafter, a second member of this family was cloned and characterized (NHERF2, also called E3KARP and TKA1) (2). NHERF and NHERF2 contain two tandem proteinprotein interactive PDZ domains. Following the demonstration that these proteins bind ezrin, a new model was… CONTINUE READING
7 Citations
13 References
Similar Papers


Publications referenced by this paper.
Showing 1-10 of 13 references

NHERF, a merlin-interacting protein, is primarily expressed in luminal epithelia, proliferative endometrium, and estrogen receptor-positive breast carcinomas

  • Stemmer-Rachamimov, A.O
  • Amer. J. Pathol
  • 2001

Platelet-derived growth factor receptor association with Na(+)/H(+) exchanger regulatory factor potentiates receptor activity

  • S Maudsley
  • Mol. Cell Biol. 22:8352–8363
  • 2000

Molecular cloning of the cDNA and promoter sequences for the mouse Sodium-Hydrogen Exchanger Regulatory Factor (NHE-RF)

  • E. J. Weinman, D. Steplock, S. Akhter, S. Shenolikar
  • Biochem. Biophys
  • 1999

Similar Papers

Loading similar papers…