New functions for an old enzyme: nonhemostatic roles for tissue-type plasminogen activator in the central nervous system.

@article{Yepes2004NewFF,
  title={New functions for an old enzyme: nonhemostatic roles for tissue-type plasminogen activator in the central nervous system.},
  author={Manuel Yepes and Daniel A Lawrence},
  journal={Experimental biology and medicine},
  year={2004},
  volume={229 11},
  pages={1097-104}
}
Tissue-type plasminogen activator (tPA) is a highly specific serine proteinase that activates the zymogen plasminogen to the broad-specificity proteinase plasmin. Tissue-type plasminogen activator is found not only in the blood, where its primary function is as a thrombolytic enzyme, but also in the central nervous system (CNS), where it promotes events associated with synaptic plasticity and acts as a regulator of the permeability of the neurovascular unit. Tissue-type plasminogen activator… CONTINUE READING