New functional domains of human cytomegalovirus pUL89 predicted by sequence analysis and three-dimensional modelling of the catalytic site DEXDc.

Abstract

INTRODUCTION Benzimidazole D-ribonucleosides inhibit DNA packaging during human cytomegalovirus (HCMV) replication. Although they have been shown to target pUL56 and pUL89, the large and small subunits of the HCMV terminase respectively, their mechanism of action is not yet fully understood. METHODS AND RESULTS To better understand HCMV DNA maturation and… (More)

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Cite this paper

@article{Champier2007NewFD, title={New functional domains of human cytomegalovirus pUL89 predicted by sequence analysis and three-dimensional modelling of the catalytic site DEXDc.}, author={Ga{\"e}l Champier and S{\'e}bastien Hantz and Anthony Couvreux and St{\'e}phanie Stuppfler and Marie-Christine Mazeron and Serge Bouaziz and François Denis and Sophie Alain}, journal={Antiviral therapy}, year={2007}, volume={12 2}, pages={217-32} }