New frontiers in the treatment of Hirschsprung disease.

  title={New frontiers in the treatment of Hirschsprung disease.},
  author={Nikhil Thapar},
  journal={Journal of pediatric gastroenterology and nutrition},
  volume={48 Suppl 2},
BACKGROUND Hirschsprung disease (HSCR) is the most common identifiable developmental disorder of the enteric nervous system (ENS), characterized by a failure of its formation in a variable segment of distal bowel. Currently available surgical therapies for HSCR, although lifesaving, are associated with an unsatisfactory long-term prognosis for many, highlighting the need for newer curative therapies. On the basis of our understanding of ENS development, 1 potential therapeutic tool relates to… CONTINUE READING