New fluoroquinolones: a class of potent antibiotics.


The discovery of antibiotics opened a new era in the treatment against several pathogenic microorganisms that can disable or kill humans. The appearance of the fluoroquinolones (based on nalidixic acid, 4-quinolone-3-carboxylates), in the early 1980's, gave a new impetus in the treatment of infectious diseases. Despite these favourable properties, the earlier fluoroquinolones had limited potency against some clinically important organisms, especially Gram-positive pathogens so that the development of resistance to these organisms has become a serious problem. Thus the development of new fluoroquinolones with a better pharmacokinetic profile, potency, broad spectrum of activity, solubility, prolonged serum half-life and oral and parenteral routes of administration has been a major focus on recent research. The increasing interest in this class led me to review the promising new fluoroquinolones in clinical trials.

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@article{Souza2005NewFA, title={New fluoroquinolones: a class of potent antibiotics.}, author={Marcus Vin{\'i}cius Nora de Souza}, journal={Mini reviews in medicinal chemistry}, year={2005}, volume={5 11}, pages={1009-17} }