New features of invasive candidiasis in humans: amyloid formation by fungi and deposition of serum amyloid P component by the host.

@article{Gilchrist2012NewFO,
  title={New features of invasive candidiasis in humans: amyloid formation by fungi and deposition of serum amyloid P component by the host.},
  author={Kevin B Gilchrist and Melissa C. Garcia and Richard E. Sobonya and Peter N Lipke and Stephen A. Klotz},
  journal={The Journal of infectious diseases},
  year={2012},
  volume={206 9},
  pages={1473-8}
}
BACKGROUND Invasive candidiasis occurs in the gastrointestinal tract, especially in neutropenic patients. We were interested in determining whether invasive fungi formed amyloid in humans as they are known to do in vitro. We also sought to characterize the consequence(s) of such amyloid formation. METHODS Tissue from 25 autopsy patients with invasive candidiasis of the gastrointestinal tract was stained with amyloidophilic dyes and for the presence of serum amyloid P component (SAP… CONTINUE READING
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