New evidence that the MHC influences odor perception in humans: a study with 58 Southern Brazilian students

@article{Santos2005NewET,
  title={New evidence that the MHC influences odor perception in humans: a study with 58 Southern Brazilian students},
  author={Pablo S C Santos and Juliano Augusto Schinemann and Juarez Gabardo and Maria da Graça Bicalho},
  journal={Hormones and Behavior},
  year={2005},
  volume={47},
  pages={384-388}
}
Increasing evidence suggests a correlation between mate choice, odor preference, and genetic similarity at the Major Histocompatibility Complex (MHC) in a variety of animals, including our species. The MHC is a highly polymorphic group of genes that play an important role in the immunological self/nonself recognition. Its products have been reported to take part on the variety of compounds and reactions that together build an individual's body odor. It has been suggested, therefore, that… Expand
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References

SHOWING 1-10 OF 24 REFERENCES
Paternally inherited HLA alleles are associated with women's choice of male odor
TLDR
It is shown that women can detect differences of one HLA allele among male odor donors with different MHC genotypes, and data indicate that paternally inherited HLA-associated odors influence odor preference and may serve as social cues. Expand
Body odour preferences in men and women: do they aim for specific MHC combinations or simply heterozygosity?
  • C. Wedekind, S. Füri
  • Biology, Medicine
  • Proceedings of the Royal Society of London. Series B: Biological Sciences
  • 1997
TLDR
No significant effect was found when tests were tested for an influence of the MHC on odour preferences after the degree of similarity between T–shirt–wearer and smeller was statistically controlled for, which suggests that in study populations the M HC influences body Odour preferences mainly, if not exclusively, by thedegree of similarity or dissimilarity. Expand
Polymorphisms in the HLA-linked olfactory receptor genes in the Hutterites.
TLDR
Three single nucleotide polymorphisms were detected in the single translated exon of this gene, all of which resulted in amino acid substitutions, which may not be sufficient to contribute to the observed patterns of mate choice in the Hutterites and to individual variation in odor preferences. Expand
MHC-dependent mate preferences in humans
TLDR
The MHC influences both body odours and body odour preferences in humans, and that the women’s preferences depend on their hormonal status, which suggests that the MHC or linked genes influence human mate choice today. Expand
The Evolution of Mating Preferences and Major Histocompatibility Complex Genes
TLDR
It is proposed that MHC‐dependent mating preferences enable hosts to provide a “moving target” against rapidly evolving parasites that escape immune recognition (the Red Queen hypothesis) and may also function to avoid inbreeding. Expand
Preweaning experience in the control of mating preferences by genes in the major histocompatibility complex of the mouse
TLDR
It is indicated that the same set of genes involved in regulation of immune function also determines, in part, mate choice and a male bias in favor of females whose MHC types differ from the male's parental MHC type could serve to promote heterozygosity at the MHC. Expand
The Effect of Early Experience on MHC-Based Mate Preferences in Two B10.W Strains of Mice (Mus domesticus)
  • A. Eklund
  • Biology, Medicine
  • Behavior genetics
  • 1997
TLDR
The results suggest that rearing environment did affect MHC-based preferences in females of this strain, although learning of self-MHC cues and use of non-M HC cues for mate choice may also occur. Expand
HLA and mate choice in humans.
TLDR
The results of this study are consistent with the conclusion that Hutterite mate choice is influenced by HLA haplotypes, with an avoidance of spouses with haplotypes that are the same as one's own. Expand
MHC and kin discrimination in juvenile Arctic charr, Salvelinus alpinus (L.)
TLDR
The results indicate that the MHC has a significant influence on the odours used for kin recognition and discrimination in juvenile Arctic charr. Expand
Control of mating preferences in mice by genes in the major histocompatibility complex
TLDR
These findings conform to a provisional model in which olfactory mating preference is governed by two linked genes in the region of H-2, one for the female signal andOne for the male receptor, and this suggests memory, but fortuitous bias is not excluded. Expand
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