New evidence of a dihydropyridine-activated cationic channel in the MDCK cell line.

@article{Melndez2011NewEO,
  title={New evidence of a dihydropyridine-activated cationic channel in the MDCK cell line.},
  author={E. Mel{\'e}ndez and Michel Bidet and Jose L Reyes and Sonia Martial and Olivier Barbier and Michel Tauc and Eladio S{\'a}nchez and Philippe Poujeol},
  journal={Nephron. Physiology},
  year={2011},
  volume={118 4},
  pages={p73-81}
}
Newborn rat distal cells express an apical Ca2+ channel activated by dihydropyridine drugs. Similarly, in Madin-Darby canine kidney (MDCK) cells, nifedipine increased Ca2+i in a concentration-dependent manner (IC50=4 μM) in fura-2-loaded cells. Response to nifedipine was abolished by EGTA, suggesting that it depends on extracellular calcium. Ca2+ channel… CONTINUE READING