New evidence for the origin of intracranial germ cell tumours from primordial germ cells: expression of pluripotency and cell differentiation markers.

@article{HoeiHansen2006NewEF,
  title={New evidence for the origin of intracranial germ cell tumours from primordial germ cells: expression of pluripotency and cell differentiation markers.},
  author={Christina Engel Hoei-Hansen and Astrid Marie Sehested and Marianne Juhler and Y F Lau and Niels Erik Skakkebaek and Henriette Laursen and Ewa Rajpert-De Meyts},
  journal={The Journal of pathology},
  year={2006},
  volume={209 1},
  pages={25-33}
}
Primary intracranial germ cell tumours are rare neoplasms that occur in children and adolescents. This study examined both the biology and the origin of these tumours, as it has been hypothesized that they originate from a totipotent primordial germ cell. We applied recent knowledge from gonadal germ cell tumours and analysed expression of a wide panel of stem cell-related proteins (C-KIT, OCT-3/4 (POU5F1), AP-2gamma (TFAP2C), and NANOG) and developmentally regulated germ cell-specific proteins… CONTINUE READING

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