New eukaryotic transcriptional repressers

  title={New eukaryotic transcriptional repressers},
  author={Shamol Saha and Joshua M Brickman and Norbert Lehming and Mark Ptashne},
TRANSCRIPTIONAL activating sequences have been described1 that are encoded by parts of the genome of Escherichia coli. These acidic peptides, fused to a DNA-binding fragment of the yeast transcriptional activator GAL4, activate transcription of a gene in a wide array of eukaryotes, provided that gene bears GAL4-binding sites nearby2–4. Here we describe an E. coil-encoded sequence that, when attached to the same DNA-binding fragment (GAL4( 1–147)), converts that fragment into a repressor. Thus… CONTINUE READING

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