New ethacrynic acid derivatives as potent cytoskeletal modulators in trabecular meshwork cells.

@article{Shimazaki2004NewEA,
  title={New ethacrynic acid derivatives as potent cytoskeletal modulators in trabecular meshwork cells.},
  author={Atsushi Shimazaki and Hiroshi Suhara and Masaki Ichikawa and Takeshi Matsugi and Koji Konomi and Yasutaka Takagi and Hideaki Hara and Ponugoti Vasantha Rao and David Lee Epstein},
  journal={Biological & pharmaceutical bulletin},
  year={2004},
  volume={27 6},
  pages={846-50}
}
A series of ethacrynic acid (ECA) derivatives were synthesized and examined for ocular hypotensive activity. Efficacy was evaluated in a cell-shape assay, using human trabecular meshwork cells, and cytotoxicity in a (3-(4,5-dimethylthiazole-2-yl)-5-(3-carboxymethoxy phenyl)-2-(4-sulfophenyl)-2H-tetrazolium) assay, using cultured bovine trabecular meshwork… CONTINUE READING