New estimates of the rates and effects of mildly deleterious mutation in Drosophila melanogaster.

@article{Fry1999NewEO,
  title={New estimates of the rates and effects of mildly deleterious mutation in Drosophila melanogaster.},
  author={James Fry and Peter D. Keightley and Stefanie L. Heinsohn and Sergey V. Nuzhdin},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1999},
  volume={96 2},
  pages={574-9}
}
The genomic rate and distribution of effects of deleterious mutations are important parameters in evolutionary theory. The most detailed information comes from the work of Mukai and Ohnishi, who allowed mutations to accumulate on Drosophila melanogaster second chromosomes, shielded from selection and recombination by being maintained heterozygous in males. Averaged over studies, the estimated rate of nonlethal viability mutations per second chromosome per generation under an equal-effects model… CONTINUE READING