New epothilone congeners from Sorangium cellulosum strain So0157-2.

@article{Wang2011NewEC,
  title={New epothilone congeners from Sorangium cellulosum strain So0157-2.},
  author={Ji-dong Wang and Nan Jiang and Hui Zhang and Lin-ping Ying and Chuan-Xi Wang and Wen-sheng Xiang and Bo Wu and Haibin Wang and Hua Bai},
  journal={Natural product research},
  year={2011},
  volume={25 18},
  pages={1707-12}
}
As a continuous work to find more epothilone congeners produced by the epothilones A and B producing Sorangium cellulosum strain So0157-2 in the large-scale fermentation (5000 L), we reinvestigated the chemical compositions of the fermentation broth. Consequently, two new epothilone variants (1-2) and one new natural epothilone derivative (3) were isolated from the fermentation broth. Their structures were established as 16-ethyl epothilone B (1), 6-desmethyl-16-hydroxymethyl epothilone C (2… CONTINUE READING

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As a continuous work to find more epothilone congeners produced by the epothilones A and B producing Sorangium cellulosum strain So0157 - 2 in the large - scale fermentation ( 5000 L ) , we reinvestigated the chemical compositions of the fermentation broth .
Their structures were established as 16-ethyl epothilone B ( 1 ) , 6-desmethyl-16-hydroxymethyl epothilone C ( 2 ) and 20-ethyl epothilone A ( 3 ) , respectively , by an extensive NMR analysis .
Their structures were established as 16-ethyl epothilone B ( 1 ) , 6-desmethyl-16-hydroxymethyl epothilone C ( 2 ) and 20-ethyl epothilone A ( 3 ) , respectively , by an extensive NMR analysis .
Their structures were established as 16-ethyl epothilone B ( 1 ) , 6-desmethyl-16-hydroxymethyl epothilone C ( 2 ) and 20-ethyl epothilone A ( 3 ) , respectively , by an extensive NMR analysis .
Their structures were established as 16-ethyl epothilone B ( 1 ) , 6-desmethyl-16-hydroxymethyl epothilone C ( 2 ) and 20-ethyl epothilone A ( 3 ) , respectively , by an extensive NMR analysis .
Their structures were established as 16-ethyl epothilone B ( 1 ) , 6-desmethyl-16-hydroxymethyl epothilone C ( 2 ) and 20-ethyl epothilone A ( 3 ) , respectively , by an extensive NMR analysis .
Their structures were established as 16-ethyl epothilone B ( 1 ) , 6-desmethyl-16-hydroxymethyl epothilone C ( 2 ) and 20-ethyl epothilone A ( 3 ) , respectively , by an extensive NMR analysis .
As a continuous work to find more epothilone congeners produced by the epothilones A and B producing Sorangium cellulosum strain So0157 - 2 in the large - scale fermentation ( 5000 L ) , we reinvestigated the chemical compositions of the fermentation broth .
As a continuous work to find more epothilone congeners produced by the epothilones A and B producing Sorangium cellulosum strain So0157 - 2 in the large - scale fermentation ( 5000 L ) , we reinvestigated the chemical compositions of the fermentation broth .
Their structures were established as 16-ethyl epothilone B ( 1 ) , 6-desmethyl-16-hydroxymethyl epothilone C ( 2 ) and 20-ethyl epothilone A ( 3 ) , respectively , by an extensive NMR analysis .
Their structures were established as 16-ethyl epothilone B ( 1 ) , 6-desmethyl-16-hydroxymethyl epothilone C ( 2 ) and 20-ethyl epothilone A ( 3 ) , respectively , by an extensive NMR analysis .
Their structures were established as 16-ethyl epothilone B ( 1 ) , 6-desmethyl-16-hydroxymethyl epothilone C ( 2 ) and 20-ethyl epothilone A ( 3 ) , respectively , by an extensive NMR analysis .
Their structures were established as 16-ethyl epothilone B ( 1 ) , 6-desmethyl-16-hydroxymethyl epothilone C ( 2 ) and 20-ethyl epothilone A ( 3 ) , respectively , by an extensive NMR analysis .
Their structures were established as 16-ethyl epothilone B ( 1 ) , 6-desmethyl-16-hydroxymethyl epothilone C ( 2 ) and 20-ethyl epothilone A ( 3 ) , respectively , by an extensive NMR analysis .
Their structures were established as 16-ethyl epothilone B ( 1 ) , 6-desmethyl-16-hydroxymethyl epothilone C ( 2 ) and 20-ethyl epothilone A ( 3 ) , respectively , by an extensive NMR analysis .
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