New enzymes involved in the mechanism of action of epidermal growth factor in a clonal strain of Leydig tumor cells.

@article{Castilla2008NewEI,
  title={New enzymes involved in the mechanism of action of epidermal growth factor in a clonal strain of Leydig tumor cells.},
  author={Roc{\'i}o Castilla and Mariana C. Gadaleta and Ana Fernanda Castillo and Alejandra Hern{\'a}ndez Duarte and Isabel Neuman and Cristina Del Valle Paz and Fabiana Cornejo Maciel and Ernesto Jorge Podest{\'a}},
  journal={Endocrinology},
  year={2008},
  volume={149 7},
  pages={
          3743-52
        }
}
The studies presented herein were designed to investigate the effect of mouse epidermal growth factor (mEGF) on arachidonic acid (AA) release in a clonal strain of cultured murine Leydig cells (designed MA-10). In MA-10 cells, mEGF promotes AA release and metabolism to lipoxygenated products to induce the steroidogenic acute regulatory (StAR) protein. However, the mechanism by which mEGF releases AA in these cells is not totally elucidated. We show that mEGF produces an increment in the… CONTINUE READING
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