New enzyme lineages by subdomain shuffling.

@article{Hopfner1998NewEL,
  title={New enzyme lineages by subdomain shuffling.},
  author={Karl-Peter Hopfner and Erhard Kopetzki and Georg Kresse and Wolfram Bode and Robert Huber and Richard Alan Engh},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1998},
  volume={95 17},
  pages={9813-8}
}
Protein functions have evolved in part via domain recombination events. Such events, for example, recombine structurally independent functional domains and shuffle targeting, regulatory, and/or catalytic functions. Domain recombination, however, can generate new functions, as implied by the observation of catalytic sites at interfaces of distinct folding domains. If useful to an evolving organism, such initially rudimentary functions would likely acquire greater efficiency and diversity… CONTINUE READING

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