New doxorubicin analogs active against doxorubicin-resistant colon tumor xenografts in the nude mouse.

Abstract

The antitumor activity of doxorubicin and three new derivatives modified on the position 4' of the amino sugar was tested against five human colon tumors and two human rectal tumors (originating from different patients) and xenografted into nude mice. The drugs tested were: 4'-epidoxorubicin; 4'-deoxydoxorubicin; and 4'-O-methyldoxorubicin. Mice were… (More)

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@article{Giuliani1980NewDA, title={New doxorubicin analogs active against doxorubicin-resistant colon tumor xenografts in the nude mouse.}, author={Fabienne Giuliani and Norman Kaplan}, journal={Cancer research}, year={1980}, volume={40 12}, pages={4682-7} }