New diterpene furanoids from the Antarctic lichen Huea sp.

  title={New diterpene furanoids from the Antarctic lichen Huea sp.},
  author={Yinglan Cui and Joung Han Yim and Dong-Sung Lee and Youn Chul Kim and Hyuncheol Oh},
  journal={Bioorganic & medicinal chemistry letters},
  volume={22 24},
In the course of ongoing research on protein tyrosine phosphatase 1B (PTP1B) inhibitory compounds from Antarctic lichens, four new diterpene furanoids, hueafuranoids A-D (1-4) have been isolated from the MeOH extract of Antarctic lichen Huea sp. by various chromatographic methods. The structures of these compounds were elucidated by analysis of NMR and MS data, and comparing their spectral data with those in the literature. Compound 1 showed inhibitory activity against therapeutically targeted… CONTINUE READING
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