New directions in the management of advanced pancreatic cancer: a review

@article{RochaLima2008NewDI,
  title={New directions in the management of advanced pancreatic cancer: a review},
  author={Caio Max S Rocha-Lima},
  journal={Anti-Cancer Drugs},
  year={2008},
  volume={19},
  pages={435-446}
}
  • C. Rocha-Lima
  • Published 1 June 2008
  • Biology, Medicine
  • Anti-Cancer Drugs
Complete surgical resection is the only potentially curative option for pancreatic cancer. However, most patients have advanced/metastatic disease at the time of diagnosis, or will relapse after surgery. Systemic chemotherapy is only palliative. Gemcitabine-based therapy is an acceptable standard for unresectable locally advanced/metastatic pancreatic cancer, but average median survival is only 6 months. The addition of other chemotherapies (including other antimetabolites, platinum, and… 

Pancreatic Cancer Treatment

Current and future clinical trials using natural compounds such as vitamin E compound delta-tocotrienol and curcumin in combination with standard chemotherapy are ongoing to discover more effective ways of treating advanced pancreatic cancer.

Emerging drugs in the treatment of pancreatic cancer

The aims of this review are to define the existing treatments available at present for patients with pancreatic cancers in the neo-adjuvant, adjuvant, locally advanced and metastatic settings, and to highlight the molecular heterogeneity of the cancers and the rationale for targeting specific oncogenic pathways.

Management of advanced pancreatic cancer

Despite the benefit of gemcitabine, most patients with advanced disease still do poorly, with a median time-to-tumor progression between 2 and 3 months and median overall survival of 4–6 months.

The role of radiotherapy in locally advanced pancreatic carcinoma

The benefits associated with local therapies, including radiotherapy and surgical resection, as they relate to improved local disease control, prolonged overall survival and improved symptom control are focused on.

Challenges in developing targeted therapy for pancreatic adenocarcinoma

The molecular heterogeneity typical of pancreatic cancers is described and targeted therapies in development are discussed, suggesting that targeting multiple oncogenic pathways using novel targeted therapies could improve patient survival.

Histone deacetylase inhibitors and pancreatic cancer: are there any promising clinical trials?

Clinical data for HDACIs in patients with pancreatic cancer are inadequate, because only a few studies have included patients suffering from this type of neoplasm and the number of Pancreatic cancer patients that entered HDACI phase II/III trials, among others with advanced solid tumors, is very limited.

Preclinical studies identify novel targeted pharmacological strategies for treatment of human malignant pleural mesothelioma

The recently described isolation of TICs from hMPM, the proposed main pharmacological target for novel antitumoural drugs, may contribute to better dissect the biology and multidrug resistance pathways controlling hM PM growth.

Current evidence for histone deacetylase inhibitors in pancreatic cancer.

HDACIs constitute a promising treatment for pancreatic cancer with encouraging anti-tumor effects, at well-tolerated doses, as well as their antiproliferative effects in animal models are presented.

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