New dictyodendrins as BACE inhibitors from a southern Australian marine sponge, Ianthella sp.

  title={New dictyodendrins as BACE inhibitors from a southern Australian marine sponge, Ianthella sp.},
  author={Hua Zhang and Melissa M. Conte and Zeinab G. Khalil and Xiao-cong Huang and Robert J. Capon},
  journal={RSC Advances},
Chemical analysis of a southern Australian marine sponge, an Ianthella sp., yielded dictyodendrins F–J (1–5) as new examples of a rare class of marine alkaloid. Structures were assigned on the basis of detailed spectroscopic analysis, while biosynthetic considerations suggested a relationship between the dictyodendrins and co-metabolites belonging to the lamellarin and ianthellidone structure classes. The dictyodendrins 1 and 3–5 exhibited significant BACE inhibitory activity (IC50 1–2 μM… 
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Total synthesis of the dictyodendrins as an arena to highlight emerging synthetic technologies.
Dictyodendrins exhibit a wide range of biological activities, such as telomerase inhibition, BACE1 enzyme inhibition, and cytotoxicity against several cancer cell lines, and provided a platform for the application of novel synthetic methods including C-H insertion, C- H arylation, and electrocyclization cascades.
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  • 2019
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A search for BACE inhibitors reveals new biosynthetically related pyrrolidones, furanones and pyrroles from a southern Australian marine sponge, Ianthella sp.
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Dictyodendrins A-E, the first telomerase-inhibitory marine natural products from the sponge Dictyodendrilla verongiformis.
Five new alkaloids, dictyodendrins A-E (1-5), were isolated from the Japanese marine sponge DictyODendrilla verongiformis as telomerase inhibitors by spectroscopic and chemical methods.
Total synthesis of dictyodendrin A and B.
The first total synthesis of dictyodendrins A and B is reported which features a hitherto unprecedented benzyne-mediated one-pot cyclization/cross-coupling sequence.
Total syntheses of the telomerase inhibitors dictyodendrin B, C, and E.
Concise and flexible total syntheses of the pyrrolo[2,3-c]carbazole alkaloids dictyodendrin B, C, and E are described, particularly noteworthy in this context is the generation of the very labile p-quinomethide motif of dictyODendrin E.
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Synthetic Approach to Telomerase Inhibitor Dictyodendrin B: Synthesis of the Pyrrolo[2,3-c]carbazole Core
The core structure of the telomerase inhibitor, dictyodendrin B, was synthesized by using the palladium-catalyzed cross-coupling reaction of
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