New dictyodendrins as BACE inhibitors from a southern Australian marine sponge, Ianthella sp.

@article{Zhang2012NewDA,
  title={New dictyodendrins as BACE inhibitors from a southern Australian marine sponge, Ianthella sp.},
  author={Hua Zhang and Melissa M. Conte and Zeinab G. Khalil and Xiao-cong Huang and Robert J. Capon},
  journal={RSC Advances},
  year={2012},
  volume={2},
  pages={4209-4214}
}
Chemical analysis of a southern Australian marine sponge, an Ianthella sp., yielded dictyodendrins F–J (1–5) as new examples of a rare class of marine alkaloid. Structures were assigned on the basis of detailed spectroscopic analysis, while biosynthetic considerations suggested a relationship between the dictyodendrins and co-metabolites belonging to the lamellarin and ianthellidone structure classes. The dictyodendrins 1 and 3–5 exhibited significant BACE inhibitory activity (IC50 1–2 μM… 
Spiralisones A-D: acylphloroglucinol hemiketals from an Australian marine brown alga, Zonaria spiralis.
TLDR
An intertidal sample of the Australian marine brown alga, Zonaria spiralis, exhibited promising kinase inhibitory and antibacterial activity, revealing for the first time that brown algal chromones may be handling artifacts rather than natural products.
Denigrins and Dactylpyrroles, Arylpyrrole Alkaloids from a Dactylia sp. Marine Sponge.
TLDR
Seven new arylpyrrole alkaloids (1-7) were isolated from an extract of a Dactylia sp.
Total synthesis of the dictyodendrins as an arena to highlight emerging synthetic technologies.
TLDR
Dictyodendrins exhibit a wide range of biological activities, such as telomerase inhibition, BACE1 enzyme inhibition, and cytotoxicity against several cancer cell lines, and provided a platform for the application of novel synthetic methods including C-H insertion, C- H arylation, and electrocyclization cascades.
Pyrrole-Derived Alkaloids of Marine Sponges and Their Biological Properties
  • K. Singh, Majik
  • Chemistry
    Studies in Natural Products Chemistry
  • 2019
Lissodendrins A and B: 2‐Amino­imidazole Alkaloids from the Marine Sponge Lissodendoryx (Acanthodoryx) fibrosa
Chemical investigatio n of the Indonesian sponge Lissodendoryx (Acanthodoryx) fibrosa yielded the new 2-aminoimidazole alkaloids lissodendrins A (1) and B (2). Their structures were unambiguously
Application of Networking Approaches to Assess the Chemical Diversity, Biogeography, and Pharmaceutical Potential of Verongiida Natural Products
TLDR
A network analysis for the NPs produced by the Verongiida sponges was applied to systematically explore the chemical space relationships between taxonomy, secondary metabolite and drug score variables, allowing for the identification of differences and correlations within a dataset.
Marine Organisms as Alkaloid Biosynthesizers of Potential Anti-Alzheimer Agents
TLDR
Alkaloids targeting more than one CI, multitarget-directed ligands (MTDL), have the potential to become a lead in AD treatment, especially if they contain halogens and amine quaternization.
Marine Pharmacology in 2012–2013: Marine Compounds with Antibacterial, Antidiabetic, Antifungal, Anti-Inflammatory, Antiprotozoal, Antituberculosis, and Antiviral Activities; Affecting the Immune and Nervous Systems, and Other Miscellaneous Mechanisms of Action †
TLDR
The peer-reviewed marine pharmacology literature from 2012 to 2013 was systematically reviewed, consistent with the 1998–2011 reviews of this series, and contributed significantly to potentially novel therapeutic approaches to several global disease categories.
...
...

References

SHOWING 1-10 OF 14 REFERENCES
A search for BACE inhibitors reveals new biosynthetically related pyrrolidones, furanones and pyrroles from a southern Australian marine sponge, Ianthella sp.
TLDR
The ianthellidones were non-cytotoxic towards two human colon cancer cell lines, as well as Gram +ve and Gram -ve bacteria, and a fungus, and Structures for all Ianthella metabolites were determined by detailed spectroscopic analysis, supported by a plausible biosynthetic relationship.
Dictyodendrins A-E, the first telomerase-inhibitory marine natural products from the sponge Dictyodendrilla verongiformis.
TLDR
Five new alkaloids, dictyodendrins A-E (1-5), were isolated from the Japanese marine sponge DictyODendrilla verongiformis as telomerase inhibitors by spectroscopic and chemical methods.
Total synthesis of dictyodendrin A and B.
TLDR
The first total synthesis of dictyodendrins A and B is reported which features a hitherto unprecedented benzyne-mediated one-pot cyclization/cross-coupling sequence.
Total syntheses of the telomerase inhibitors dictyodendrin B, C, and E.
TLDR
Concise and flexible total syntheses of the pyrrolo[2,3-c]carbazole alkaloids dictyodendrin B, C, and E are described, particularly noteworthy in this context is the generation of the very labile p-quinomethide motif of dictyODendrin E.
Aldose reductase inhibitors from a marine sponge, Dictyodendrilla sp.
Three potent aldose reductase inhibitors (1a, 1b, 2a) with a unique pyrrolo[2,3-c]carbazole skeleton isolated from a marine sponge, Dictyodendrilla sp., were characterized by chemical and physical
Total synthesis of dictyodendrin B.
TLDR
It was shown that global deprotection of the peripheral -OH groups in pyrrolo[2,3-c]carbazole 13 is accompanied by spontaneous air-oxidation to form the quinone core of dictyodendrin C, a scarce marine alkaloid endowed with promising telomerase inhibitory activity.
Synthetic Approach to Telomerase Inhibitor Dictyodendrin B: Synthesis of the Pyrrolo[2,3-c]carbazole Core
The core structure of the telomerase inhibitor, dictyodendrin B, was synthesized by using the palladium-catalyzed cross-coupling reaction of
Evaluation of a tetrazolium-based semiautomated colorimetric assay: assessment of radiosensitivity.
TLDR
While optimal conditions for each cell line (cell number plated and doubling time) must be established, the 3-dimethylthiazol-2-yl)-2,5-diphenylformazan bromide assay could be automated and thus be of great value in screening large numbers of potential radiosensitizers or protectors.
...
...